Penicillin and cephalosporin resistance in gonococci.

Penicillin and cephalosporin resistance in gonococci.

Non-penicillinase producing Neisseria gonorrhoeae isolated at St Mary's Hospital, London were examined for the prevalence of resistance to penicillin and for decreased susceptibility to cefuroxime. Of the 941 non-PPNG tested 100 (10.6%) were resistant to penicillin (minimum inhibitory concentration, MIC, greater than or equal to 1 mg/l) and were considered to be chromosomally-resistant N gonorr...

Penicillin sensitivity of gonococci in Ethiopia.

This study was made to determine whether strains of Neisseria gonorrhoeae with increased resistance to penicillin were present in Ethiopia. The emergence of such strains elsewhere in the world has been amply noted. This has been associated with an increase in both the number oftreatment failures and the number of reported gonococcal infections. The African continent is thought to share in this ...

Validity of reports of penicillin-resistant gonococci.

Cephalosporin MIC creep among gonococci: time for a pharmacodynamic rethink?

BACKGROUND Gonorrhoea has been among the easiest infections to cure with antibiotics. Nevertheless, emerging resistance has driven repeated treatment shifts. Decreased cephalosporin susceptibility is now being reported. We examined cephalosporin MIC trends for Neisseria gonorrhoeae in the UK and undertook pharmacodynamic analyses to predict efficacy against strains with raised MICs. METHODS N...

Resistance to penicillin and cephalosporin and mortality from severe pneumococcal pneumonia in Barcelona, Spain.

BACKGROUND Penicillin-resistant strains of Streptococcus pneumoniae are now found worldwide, and strains with resistance to cephalosporin are being reported. The appropriate antibiotic therapy for pneumococcal pneumonia due to resistant strains remains controversial. METHODS To examine the effect of resistance to penicillin and cephalosporin on mortality, we conducted a 10-year, prospective s...